Pharmaceutical & Life Sciences
Adamantane & Dihydrazide-dihydrazone Group Compound, represented by A2P Care Pharmaceuticals LLP
The patented compound merges the therapeutic power of adamantane and dihydrazide-dihydrazone groups, known for their efficacy in treating Type 2 diabetes, neurological disorders like Parkinson’s and Alzheimer’s, and cancer. The dihydrazide-dihydrazone ability to address anti-diabetes and hypertension gives it an edge over existing treatments.
Overview
Our patented compound contains adamantane and dihydrazide-dihydrazone groups, both of which are known for their medicinal properties, as demonstrated in numerous literature reviews. The compound holds promise in the treatment of several diseases, especially cancer, neurological disorders, and diabetes.
Adamantane Derivatives:
Widely recognized for their efficacy in treating neurological conditions, such as Parkinson’s disease and Alzheimer’s disease, adamantane-based compounds are expected to play a pivotal role in the pharmaceutical industry in the near future. According to existing research, adamantane’s ability to mitigate neurological complications associated with Type 2 diabetes further strengthens its therapeutic potential.
Dihydrazide-Dihydrazone Compounds:
Known for their effectiveness against hypertension and diabetes, these compounds also exhibit various other pharmacological activities. The literature highlights the specific benefits of hydrazide/hydrazone derivatives in inhibiting alpha-glucosidase, a key enzyme related to Type 2 diabetes management.
Patent Application No.: : 202221033544
PCT Patent No.: WO2023237924A1
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HIPATONE
HIPATONE stands out as a revolutionary solution in the landscape of liver treatment for several compelling reasons. It harnesses the power of nature through a meticulous blend of extracts from Curcuma longa, Phyllanthus emblica, and Gymnosporea montana, each renowned for their hepatoprotective and medicinal properties. Not only does it address the symptoms of liver dysfunction like jaundice, but it also targets the underlying causes with its potent anti-inflammatory and antioxidant properties. By reducing liver inflammation and protecting liver cells from oxidative damage, Hipatone not only alleviates current symptoms but also prevents further deterioration of liver function.
The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a broad spectrum of adverse drug effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the host. Many drugs may affect the liver adversely in more than one way, ascited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment CLINICAL INDICATIONS LIVER DYSFUNCTION & JAUNDICE DETOXIFY LIVER THROUGH NATURAL SOURCE OF COMPOUNDS. This list is just a general guideline. Many drugs affect the liver to one degree or another and we can’t list all of them here; new drugs are always being approved for general use. “Liver Malfunction-Jaundice” – novel research composition signifies that HIPATONE®isanalytically and clinically proven safeand effective
Patent Application No.: 153/MUM/2011 (NBA Approval awaited)
US Patent No.: US8431167B2
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CARDIMODE
CARDIMODE stands out as a beacon of hope in the realm of cardiovascular health, offering a compelling solution backed by science and nature. With its unique blend of botanical ingredients, including Terminalia arjuna, Camellia sinensis, and Trikatu, this proprietary herbal medicine presents a promising avenue for individuals seeking to manage their cholesterol levels and safeguard their heart health. Through its targeted action on LDL (bad) cholesterol reduction and HDL (good) cholesterol elevation, this herbal supplement offers a holistic approach to cholesterol management, addressing a key risk factor for heart disease.
LITERATURE: UNDERSTANDING HEART ATTACK
A heart attack, or myocardial infarction, occurs when a blood vessel supplying the heart muscle is suddenly blocked by a blood clot. This blockage typically arises from the accumulation of cholesterol and other fatty substances within the blood vessel, forming plaque. Over time, plaque buildup narrows and hardens the arteries, a condition known as atherosclerosis. Reduced blood flow to the heart can lead to symptoms such as chest pain (angina) and, if left untreated, permanent damage to the heart muscle.
CARDIMODE Heart is vulnerable to a myriad of risk factors that contribute to heart disease. These include smoking, high cholesterol, high blood pressure, diabetes, obesity, and a sedentary lifestyle, collectively posing a significant threat to cardiovascular health. Plaque accumulation in the arteries, often triggered by elevated cholesterol levels and other risk factors, can culminate in partial or complete blockages, precipitating heart attacks. Additional risk factors encompass genetic predisposition, metabolic syndrome, heavy alcohol consumption, stress, sleep apnea, and certain medical conditions like preeclampsia. Embracing a healthy lifestyle, characterized by regular exercise, a balanced diet, smoking cessation, and effective stress management, is imperative in averting heart disease and mitigating the-likelihood of heartattacks.
Patent Application Number: WO2013021302A
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Masktag: Accessory Device For Face Coverings
Accessory Device for Face Coverings
The described invention pertains to an accessory device designed to address various issues associated with the use of face coverings, surgical masks, and filtering facepieces, especially in the context of the COVID-19 pandemic. Here’s an overview of the problem it aims to solve and the features it offers:
Problem Statement:
The widespread use of face coverings and masks in response to health emergencies, such as the COVID-19 pandemic, has highlighted several challenges and shortcomings associated with these protective devices. Some of the key issues include:
1. Difficulty in recognizing one’s mask after temporary removal, which poses a risk of using a contaminated mask.
2. Impaired recognizability of the wearer due to the partial coverage of the face by the mask, particularly exacerbated when wearing additional accessories like glasses or hats.
3. Accumulation of unpleasant odors inside the face covering, primarily caused by the user’s breath.
4. Build-up of microbial and viral load within the face covering due to prolonged use and favorable microclimatic conditions, potentially leading to health risks.
CARDIMODE Heart is vulnerable to a myriad of risk factors that contribute to heart disease. These include smoking, high cholesterol, high blood pressure, diabetes, obesity, and a sedentary lifestyle, collectively posing a significant threat to cardiovascular health. Plaque accumulation in the arteries, often triggered by elevated cholesterol levels and other risk factors, can culminate in partial or complete blockages, precipitating heart attacks. Additional risk factors encompass genetic predisposition, metabolic syndrome, heavy alcohol consumption, stress, sleep apnea, and certain medical conditions like preeclampsia. Embracing a healthy lifestyle, characterized by regular exercise, a balanced diet, smoking cessation, and effective stress management, is imperative in averting heart disease and mitigating the-likelihood of heartattacks.
Patent Application Number: WO2013021302A
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Patent Protected Modular Urinal for Bed Ridden People
About Us
IIPRD is representing Peeshcute in an IP Licensing mandate for a technology which Empowers Convenience and Independence for those with limited mobility issues.
Peeschute’s modular urinal tech has been carefully designed considering factors like non-invasiveness, ease of use, hygiene, sustainability, reduced dependability and reduced risk of infections.
- Established in 2018, Peeschute is a renowned brand specializing in developing innovative solutions for sanitation.
- Peeschute has developed urinal products for travel, healthcare/homecare and outdoor spaces.
- Peeschute’s flagship product includes pocket sized disposable urine bags which solidifies up to 850 ml of urine instantly to keep it leak proof, odorless and hygienic.
- Peeschute’s products have been accoladed with national and international attention including media, organizational collaborations with government and non-government bodies.
Patent Application No: 202221026004
Registrations Design Number: 373040-001 and 373041-001
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“Resoil” presented by Envit Ltd.
ReSoil® is an internationally patented, groundbreaking remediation solution that enables closed-loop removal of heavy metals from contaminated soils through a zero-emission process with no wastewater, while preserving soil as a natural substrate.
• Soil contamination with heavy metals is a global problem.
• Heavy metals include toxic metals such as lead (Pb), cadmium (Cd), copper (Cu) and zinc (Zn) as well as toxic metalloids such as arsenic (As) and antimony (Sb).
• Soils absorb decades of pollution from industry, intensive agriculture, traffic, waste, etc. Heavy metals are not degradable and remain in the soil.
• According to a recent conservative estimate, there are 2.8 million potentially contaminated sites in the EU (EEA, 2023).
• In China, 1/6 of the total cultivated area is contaminated with heavy metals (Yao et al., Proc Env Sci 2012, 16, 722-729).
• In New York, 71% of garden soils exceed the limits for lead and arsenic (Chenget al., Soil Sci 2015, 180, 167-174).
• Arsenic and lead are the 1st and 2nd most dangerous environmental pollutants
(ATSDR 2017).Lead distribution in surface soil of the conterminous United States (USGS 2014).
• Arsenic is highly toxic, long-term exposure can cause cancer.
• Lead is a neurotoxin; in the USA, the average lead-related loss of cognitive ability was 2.6 IQ points per person as of
2015 (McFarland et al. PNAS 2022, 119, e2118631119
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Patent Application Number: WO2022184903
Machine to Dispose off used Sanitary napkins chemically
Current methods of disposal and associated danger
1. Flushing and burying
• leads to blockages, plumbing problems
• outer layer of sanitary napkin is non-degradable
• collection of napkins in heaps block the pipeline
• pollute streams and rivers
• causes hormonal changes in wildlife – enable harmful organisms in the food chain
2. Incineration
• Harmful gas emissions: dioxin, furan, nitrogen oxides, sulphur dioxide, hydrochloric acid, mercury
• Ash produced contain heavy metals like lead, cadmium, copper, zinc
• Dioxins: cancer, immune system damage, reproductive and developmental problems.
• Halogenated hydrocarbons, acid gases – impair lung function.
Objectives of the new machine
• Disposal of sanitary napkins properly, thereby wiping out the risks involved in flushing, burying, and incineration.
• Reduce pollution and health hazards of conventional methods of sanitary waste disposal.
• Reduce cost for proper disposal of sanitary napkins, tampons, baby diapers and under pads.
• Simplify the process of sanitary waste disposal.
• Help in solving greatest problem people face daily.
Key Points of the machine
• One machine- can be used for sanitary napkins, tampons, baby diapers and under pads. (If a method to choose the option while
using the machine is implemented)
• Can be manufactured both – domestic (for households) and industrial size (waste disposal plants/ panchayats)
Patent Application Number: 298227
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DIABETES CARE – MEDICAL DEVICE FOR TISSUE OXIMETRY
The Opportunity
Blackhawk Technologies, LLC is exclusively representing HyperMed Imaging Inc. (the“Company”) to monetize its’ assets related to a Medical Device for Tissue Oximetry for Diabetes Care. The offering includes an FDA cleared product used by clinicians and backed by 24 patent families comprising of 62 total assets.
The Company’s pioneering technology has been in service since 2006 and has been validated in third-party published papers that assessed oxyhemoglobin, deoxyhemoglobin, and oxyhemoglobin saturation in superficial tissue for diabetic patients. The Company’s FDA 510(k) cleared product, Hyper View™, quickly determines levels of oxyhemoglobin, deoxyhemoglobin and oxygen saturation in superficial tissue in a small and portable configuration.
The Company seeks a strategic acquirer/licensee with both resources and channels to fully commercialize Company’s IP assets.
The Unmet Medical Need
Most medical exams need quick and accurate determination of superficial tissue oxygenation. For example, complications in diabetes and/or peripheral arterial disease increases risk of lower limb ischemia, chronic wounds, amputation or even death.
• Over 420 million people worldwide (1 in 11 people) have diabetes and the number is increasing rapidly.
• More than 29 million Americans have diabetes. Another 86 million have prediabetes, which is 1 in 3 US adults.
• 8.5 million Americans have peripheral arterial disease and among them nearly 2 million people in the USA are living with limb loss.
• The main causes are vascular disease (54%), including diabetes and peripheral arterial disease.
• Approximately 185,000 amputations occur in the United States each year, costing over $8 billion.
• People with diabetes are at greater risk for severe peripheral arterial disease and are five times more likely to require an amputation.
• It is estimated that a low
Hyperspectral Imaging Benefits
• Non-contact color-coded images depicting concentrations of oxyhemoglobin & deoxyhemoglobin, and oxygen saturation without injectable contrast agents.
• Readings are predictive of wound healing and can be used in screening for peripheral vascular disease.
• Software tools allow clinicians to analyze specified areas within the image to localize ischemic tissue.
• Offers improved patient care with speed, ease of use, and clinical efficiency without injectable contrast or physical contact of the device with the patient.
• Safe, using visible light and spectrometer imaging to quantify light absorption in hemoglobin molecules for rapid analysis without leaving the exam room.
For more details about technology: Click Here
DIABETES CARE – MEDICAL DEVICE FOR TISSUE OXIMETRY
The Opportunity
Blackhawk Technologies, LLC is exclusively representing HyperMed Imaging Inc. (the“Company”) to monetize its’ assets related to a Medical Device for Tissue Oximetry for Diabetes Care. The offering includes an FDA cleared product used by clinicians and backed by 24 patent families comprising of 62 total assets.
The Company’s pioneering technology has been in service since 2006 and has been validated in third-party published papers that assessed oxyhemoglobin, deoxyhemoglobin, and oxyhemoglobin saturation in superficial tissue for diabetic patients. The Company’s FDA 510(k) cleared product, Hyper View™, quickly determines levels of oxyhemoglobin, deoxyhemoglobin and oxygen saturation in superficial tissue in a small and portable configuration.
The Company seeks a strategic acquirer/licensee with both resources and channels to fully commercialize Company’s IP assets.
The Unmet Medical Need
Most medical exams need quick and accurate determination of superficial tissue oxygenation. For example, complications in diabetes and/or peripheral arterial disease increases risk of lower limb ischemia, chronic wounds, amputation or even death.
• Over 420 million people worldwide (1 in 11 people) have diabetes and the number is increasing rapidly.
• More than 29 million Americans have diabetes. Another 86 million have prediabetes, which is 1 in 3 US adults.
• 8.5 million Americans have peripheral arterial disease and among them nearly 2 million people in the USA are living with limb loss.
• The main causes are vascular disease (54%), including diabetes and peripheral arterial disease.
• Approximately 185,000 amputations occur in the United States each year, costing over $8 billion.
• People with diabetes are at greater risk for severe peripheral arterial disease and are five times more likely to require an amputation.
• It is estimated that a low
Hyperspectral Imaging Benefits
• Non-contact color-coded images depicting concentrations of oxyhemoglobin & deoxyhemoglobin, and oxygen saturation without injectable contrast agents.
• Readings are predictive of wound healing and can be used in screening for peripheral vascular disease.
• Software tools allow clinicians to analyze specified areas within the image to localize ischemic tissue.
• Offers improved patient care with speed, ease of use, and clinical efficiency without injectable contrast or physical contact of the device with the patient.
• Safe, using visible light and spectrometer imaging to quantify light absorption in hemoglobin molecules for rapid analysis without leaving the exam room.
IONOJET TM
Has developed a proprietary device (“IonojetTM”) that generates nitric oxide (“NO”) from atmospheric air in the form of a high-energy plasma/NO stream and delivers it to targeted locations of the body.
The plasma/NO stream has been shown in investigations to date:
(i)to be non-toxic
(ii) to generate NO activity up to 3 cm below the skin
(iii) to stimulate sustained biological activity in tissue for up to an hour after delivery of the therapy, and
(iv) to penetrate and disrupt biofilm
Has identified over 40 target indications in seven clinical areas based on NO’s recognized ability to:
- Increase blood flow
- Destroy pathogens (bacterial, viral and fungal)
- Regenerate tissue
- Control pain and inflammation
Has completed a dose-ranging feasibility clinical trial in the U.S. for initial target indication (Diabetic Foot Ulcers, “DFU”) to identify optimal dose & demonstrate preliminary safety/efficacy data for the device.
- Has completed PoC studies in certain target indications
- Intends to initiate PoC studies in a number of additional indications
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Nutrition Innovation In Singapore
White refined sugar is almost pure sucrose. This sucrose is consistently shown in research to be quickly absorbed into the blood stream causing rises in blood sugar levels. This in turn has contributed to the global obesity and diabetes crisis.
The Nucane™ specification of raw sugar is scientifically tested to ensure that this absorption is reduced.What the unique Nucane™ process achieves is to retain at a high level the natural organics, antioxidants and polyphenols that exist in raw sugar cane, delivering a carbohydrate that is less processed, less refined, and which has been demonstrated scientifically to reduce the metabolism of sugar into the blood stream when consumed.
This means that it is a low glycemic sugar when tested to the internationally agreed ISO 26442:2010 method.Just as importantly, our technology system ensures that Nucane™ is precise and consistent at industrial scale in primary sugar mills around the world. By eliminating the refining process and applying the Nucane technology at sugar mills, Nucane™ is a less processed, less refined, high in polyphenols specification of raw sugar which has been tested to be low glycemic to international standards.
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Prosthetic Devices Coated With Heated Cross-Linked Fibrin
Invention relates to methods of coating the surface of prosthetic devices with fibrin and drying the fibrin-coated prosthetic devices at moderately-high temperatures for extended periods of time under low atmospheric pressure to obtain prosthetic devices coated with stable cross-linked fibrin capable of binding cells and thereby capable of integrating into tissues.
Patent Application Number: WO2010/131249
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Preparation Process Of An Intermediate Used In Synthesis Of Atorvastatin
Invention relates to a impurity free preparation process of 4-fluoro-.alpha.-[2-methyl-1-oxopropyl]-y-oxo-n-beta-diphenylbenzenebutanamide, a key intermediate for the synthesis of Atorvastatin. Atorvastatin a drug useful for lowering blood cholesterol, stabilizing plaque and preventing stroke through anti-inflamatory and other mechanisms.
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Iontophoretic Device For Drug Administration To The Eye
Invention relates to a drug delivery device which is portable, easy to use iontophoretic device that ejects a high content of drug from a soft gel upon application of a low current. The device is intended to safely apply large amounts of drug to the posterior ocular tissues and to replace the use of recurrent intravitreal injections, therefore preventing the pain and complications that patients are forced to deal with today.
Patent Application Number: WO2005/084748
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Process For The Production Of Low Cholesterol Ghee
Invention relates to a process for preparation of ghee of reduced cholesterol from melted butter serum without the homogenization. Process involves adding Beta cyclodextrin 1 % to 10 % by weight of total fat content in the butter serum, adding to the melted butter serum at a temperature in the range of 35 oC to 65 oC, agitating, separating cholesterol-beta cyclodextrin complex from the butter serum and collecting concentrated butter fat serum of reduced cholesterol content and heating.
Patent Application Number: WO2010/140164
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Reusable Transition Metal Complex Catalyst For Preparing 3,3-Diaminobenzidine
Invention provides a reusable transition metal complex catalyst. Transition metal complex catalyst is useful for the preparation of high pure quality 3,3-diaminobenzidine and its analogues. Tetraaminobiphenyl prepared using transition metal catalyst is a valuable intermediate for example used as a monomer in the preparation of polybenzimidazole polymers.
Microfluidic Test Systems With Gas Bubble Reduction
Invention relates to a reservoir for use in testing a liquid as part of a microfluidic testing system includes testing chamber, a liquid inlet coupled to the testing chamber and a gas outlet. This system reduces or prevents the presence of gas bubbles and also can be utilized in a variety of testing regimes.
System For Optically Analyzing A Substance
Invention relates to a microfluidic analysis system for optically analyzing a substance includes a light source having a plurality of selectable single-wavelength light sources, a substance presentation member optically coupled to the light source and an optical detection system. This system is less expensive, easy to transport and doesn’t require large sample volumes.
Microfluidic System Utilizing Thin-Film Layers To Route Fluid
System for microfluidic processing and analysis of samples includes a microfluidic device having a substrate and a thin-film layer formed on the substrate. This system allows analyzing samples in small volumes of liquids, providing more economical use of reagents and sample and also speeding assays.
Method And System For Shedding Load In Physiological Signals Processing
Invention relates to a method for shedding load in physiological signals processing includes steps of issuing a load shedding policy, transmitting the issued load shedding policy to device and discarding portions of the signal at device according to pattern until fraction of the signal is discarded. This system allows monitoring with significant power saving and reduced loss of detection quality.
System For Diagnosis Of Glycated Hemoglobin
Invention relates to a System for measuring glycated hemoglobin, comprises a microfluidic coupon, at least one capillary channel on the microfluidic coupon that encloses a solution capable of forming a solution density gradient, a sample well in connection with the capillary channel and configured for adding a sample containing red blood cells. This system obtains HbA1c levels which are red blood cells age specific and thus accurate diagnosis of diabetes.
Tablet-In-Capsule Device For Programmed Drug Delivery System
Invention relates to a novel time dependent pulsed release system containing tablet in capsule for programmed release of drug for targeted delivery particularly salbutamol sulphate for the treatment of nocturnal asthma. Composition comprises impermeable capsule body and a soluble cap and at least two tablet formulations of which one is uncoated tablet comprising drug with pharmaceutical excipients that releases first pulse of drug as immediate release and another tablet that releases second pulse of drug as delayed release.
Herbal Compositions For Treatment Of Inflammation And Arthritis
Invention relates to herbal composition for treatment of inflammation and arthritis comprising extract of at least one bioactive portion and/or powder of one or more medicinal herbs such as Sesbania grandiflora, Sesbania sesban and Terminalia chebula. This composition has no side effects, safe, has a long shelf life, inexpensive, and cost effective.
Pharmaceutical Compositions For Enhancement Of Oral Bioavailability Of Ester Prodrug
Invention relates to pharmaceutical formulation for enhancing the oral bioavailability of a prodrug ester as a non-aqueous formulation by formulating the ester prodrug such as Cefuroxime axetil with medium chain triglycerides. The prodrug is selected from antibiotics, corticosteroids, Non-Steroidal anti-inflammatory drugs, Anti-retroviral and Angiotensin II antagonists. The Preparation method is simple, cost effective, practical and reproducible for enhancement of the bioavailability.
Proliposomal Formulations For Cancer Therapy
Invention relates to site specific formulation for effective treatment of cancer. Proliposomal formulation for effective treatment of cancer comprises therapeutically effective amount of anticancer agent, phospholipids, cholesterol and coating polymer. The anticancer agent is paclitaxel , and the phospholipids are egg phosphatidylglycerol and distearoyl phosphatidylcholine.
Preparation Of Anhydrous Rare Earth Metal Halides
The invention relates to Preparation of anhydrous rare earth metal halides from their hydrates comprises preparing slurry of rare earth metal halide hydrate in an organic solvent, refluxing and azeotropic distillation for quantitative removal of surface and bond water. This prepared anhydrous rare earth metal halides particularly halides and more specifically anhydrous cerium chloride has wide range of applications in electrochemical reduction process for production of metal and as catalyst in the addition of organometallic to carbonyl group to form corresponding alcohols.
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Anti HIV: Bioactive Composition
Invention relates to bioactive composition and its preparation process comprising curcumin, cyprenone, ursolic acid, vinflunine, berberin sulfate and other additives like diluents, binder, disintegrants and lubricants. Composition safely and effectively removes the HIV antigen glycoproteins without any major side effects and also helps to control p17 and p24 antigen levels. Present composition can be used as a dietary supplement.
Patent Pending in South Africa, India, US, and EP
Plant Extract Composition For Liver Dysfunction-Jaundice
Invention relates to the plant extract composition for treatment of liver dysfunction, jaundice and its processing steps of preparing the plant extract composition comprises extract of Curcuma longa, Phyllanthus emblica and Gymnosporea montana and carrier. The present composition exhibits superior activity in the treatment with no side effects.
Painless Treatment Of Warts
The invention relates to Painless Treatment of dermatological conditions especially Warts, Corns & Callus comprising soluble sulphide of alkali or alkaline earth metals or their combination in solvents and eutectic mixture of Lidocaine and prilocaine in an oil in water emulsion. The sulfide component in the composition dissolves the hyperkeratotic epidermis and facilitates the penetration of the topical anesthetic component.
Patent Application Number: PCT/IN2010/000001
Metal Nanosponges
The subject matter relates to a single step process for preparation of template and polymer free metal nanosponges having porous low density, high surface area, high gas permeability and thermal conductivity. Metal nanosponges are widely used in catalysis, fuel cells and membranes and as substrate for surface enhanced raman spectroscopy, as optical limiter and as antibacterial for purification/filtration of water.
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Detection Of Bacteremia
This invention relates to medical diagnostics for the detection of gram nature of pathogens in the blood with less detection time compared to the present available technologies using unique PCR based detection process.
Sterilisation Of Male Condom
This technology is about sterilisation of Male condom using 60Co gamma ray irradiation and by which Urinary tract infection caused by the microbes present on the lubricants of condom can be prevented.
Pathogen Resistant Transgenic Plant
The technology relates to a pathogen resistant transgenic plant. Transgenic plant comprises a nucleic acid molecule of a pathogen, the nucleic acid molecule is homologous to a member selected from a group consisting of polynucleotide coding for a protein, a complementary sequence or the combination with a spacer nucleotide sequence.
Controlled Release Formulations Of Anti-Tubercular Drugs
The subject matter relates to Microparticle-based drug delivery systems. More specifically, it relates to such drug delivery systems wherein the drug(s), preferably anti tubercular drugs are prepared in a Fixed Dose Combination in a manner to increase their bioavailability in the intestinal area by by-passing the gastric environment of the stomach. The present invention follows a novel approach by using pH sensitive polymers and specific targeting markers.
Indian Patent Applied
Tablets With Enhanced Dissolution Rate
The present technology provides tablets with enhanced dissolution rate of sparingly soluble drugs leading to increased bioavailability. Grains of solid dispersion of the drug in water soluble carrier are formed/cemented into tablets in a manner similar to that of cube sugar. Solid dispersions of drugs in carriers of poor compressibility can be easily formed into tablets of any suitable shape/size by known cube sugar technology. Resulting tablets are not only readily dispersible owing to capillary action but also ensure rapid dissolution of poorly soluble drug because of solid dispersion. Simultaneous exploitation of well-known approaches- solid dispersion, capillary action, optional surfactant and optional size reduction in the proposed technique results in steep enhancement of dissolution rate without compromising with content uniformity.
Status of Patent: Indian Patent Granted
Pharmaceutical Nanoelastic Vesicular Systems
The present invention relates to non-ionic surfactant based nanoelastic vesicular systems comprising fluconazole or its pharmaceutically acceptable salts, solvates, enantiomers, polymorphs or mixtures thereof, processes for preparing the same and methods of use and treatment.
Novel Controlled Release Tablet Of Poorly Soluble Drug
The subject matter relates to a novel attempt by the inventors to a controlled release dosage form for a range of poorly soluble drugs, especially, Carvedilol. The dosage form of the present invention uses a novel combination of solubilizer and a hydrophilic swellable polymer to create a better and efficient controlled release formulation for poorly soluble drugs.
Nano-Technology Based Herbal Topical Formulations
The patent pertains to the field of topical herbal formulations based on nano technology having therapeutic properties. The subject matter relates to nano-emulsion based topical synergistic herbal formulations which are effective against acne and other skin disorders. More specifically, the present invention is concerned with the prophylactic and therapeutic topical treatment of skin disorders of all types of acne, eczema, psoriasis, aging, scaring and the like.
Antibiotic Fixed Dose Combination
Fixed Dose Combination of two antibiotics: cefepime hydrochloride (a cephalosporin) and amikacin sulphate (an aminoglycoside) administered as a single product. The product is developed to overcome multi bacterial, complicated hospital acquired ICU infections particularly in deadly diseases like Nosocomial Pneumonia and Febrile Neutropenia.
Patent Granted in India, South Africa, and South Korea. Patent Pending in multiple other geographies
Delamination Of Laminated Packaging Refuse
The invention relates to a process for recovery of useful constituents from multilayer laminated fragments arising as waste from industrial packaging manufacture. It relates more particularly to recovery of polyethylene plastic and aluminium foil from multilayered, laminated fragments containing these materials. According to the process disclosed, the delamination of the laminated constituents of the packaging waste fragments is carried out by keeping the fragments immersed in nitric acid of 50 – 70 % concentration at ambient temperature for 3 to 6 hour duration. The aluminium foils get fully separated from the plastics and the constituents remain in a submerged/floating condition. The delaminated constituents are removed from the nitric acid bath and allowed to pass through a series of baths for washing and separation of the materials. The fragments of separated aluminium foils and separated plastic are centrifuged to dryness and then allowed a sun bath for total drying. The separated fragments of aluminium foils can be used for producing aluminium ingots or sold as such. Similarly the separated fragments of plastic can be used for producing recycled plastic granules or sold as such. Click here for complete project presentation.
Patent Granted in India (IN 209755), Europe, Canada, and Israel.
PCT Application Number: PCT/IN2001/000218
Biodegradable Polymer Compositionx
The invention disclosed in this application relates to a novel biodegradable additive polymer composition useful for the preparation of biodegradable plastic products which comprises of a mixture of (i) a polymer selected from Polyethylene, polypropylene, poly styrene, poly vinyl chloride or a mixture thereof (ii) Cellulose ( iii) Amides ( iv) nutrients selected from Blue green algae and / or Yeast and (v) Water. This composition can be mixed with a virgin polymer to get a master polymer. The master batch composition may be mixed with a virgin polymer, which is useful for preparing products which are biodegradable.
Patent Pending in India, United States, Europe, and other major geographies.
PCT Application Number. PCT/IN2007/000165
Lime Stone And Navasar Based Multi-Purpose Composition
The present invention relates to a Lime Stone (Calcium Carbonate)and Navasar (Ammonium Chloride) Based Multi-Purpose Composition.
Patent Application Number. 1348/MUM/2007
Blood-Based Epigenetic Bio Marker Of Human Cancer
The present invention relates to a novel and ideal bio-marker of human cancer, which meets all three characteristics formulated by the international Predictive Safety Testing Consortium (PSTC) comprising industries, nonprofit organizations and regulators (including FDA and EMEA/EMA). A non-radioactive, highly sensitive, reproducible assay to quantitatively estimate the bio-marker using a minimally invasive quick process that does not require hospitalization has been developed and standardised. The design of a complete and easy-to-use prototype for this test has already been developed in a diagnostic kit that can reliably and reproducibly detect multiple types of cancer within a short time of less than 60 min, using a minimally invasive OPD procedure requiring no hospitalization, and provides quantitative measurements of treatment efficacy and cancer retardation. The novel diagnostic kit is highly reliable and portable to remote locations without compromising efficacy.
Patent Application Number: 1791/KOL/2008
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Safety Isolation Bag For Power Morcellation
The present innovation relates to the “Safety Isolation Bag”, a pneumoperitoneum device for intra-abdominal, endoscopic procedures, power morcellation, and vaginal morcellation for facilitating safe removal of body mass from within the abdominal cavity. It comprises of an expandable and collapsible enclosed internal space having a neck portion with the mouth having re-tractor means and provided with markings, color-coded indicating how much the bag is to be pulled out for the removal of large, medium, and small tissue mass, and also having one or more non-return valves attached with long looped threads on one of the surfaces in the wall of the safety isolation bag below the neck as a means for introducing the surgical instruments and accessories into the enclosed internal space at the right place and to close the puncture hole after the procedure. It is made of one or more layers of flexible biocompatible/medical-grade plastic film.
PCT Patent Application No. : PCT/IN2015/000420
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Voriconazole Topical Antifungal Microemulgel
The invention relates to the formulation of voriconazole topical antifungal microemulgel. As compared to gel and other topical preparations microemulgel has been prepared by screening of oils, emulsifier, and co-emulsifier on bases of solubility of an API in it. An API has high solubility and oil may also have more or less pharmacological property, so it may assist the therapeutic action of API. Due to presence of oil portion, it leads to more penetration of API in the skin. Oil Micelle Size is less than 500 nm which provides more area for absorption of API in the skin so more penetration and more effective than macro-emulsion. Microemulgel has an advantage of emulgel that has dual benefits of micro-emulsion and gel and several other desirable properties like good consistency, thyrotrophic, greaseless, easily spreadable as well as removable, emollient, non-staining, water soluble, longer shelf-life, bio-friendly, transparent, pleasant appearance, ability of patients for self-medication, termination of medications will be easy, etc.
Indian Patent Application 3169/MUM/2014
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Voriconazole Transdermal Spray
The patent pertains to the field of Topical pharmaceutical formulation containing Voriconazole. The antifungal microemulgel aims at reducing side effects of the drug combining it with the advantages of emulgel. Voriconazole a triazole antifungal medication is generally used to treat serious, invasive fungal infections like candidiasis aspergillosis etc. The drug is loaded on to microemulgel, which has been prepared by screening of oils, emulsifier, and co-emulsifier on basis of solubility of desirable API in it. Voriconazole has high solubility in Neem oil which also assists in its therapeutic action. Presence of oil portion facilitates better penetration of API in the skin. Oil Micelle Size being less than 500 nm provides more area for absorption of API in the skin enhancing its efficacy. Microemulgel has an advantage of emulgel and micro-emulsion; combining several desirable properties like good consistency, thyrotrophic, greaseless, easily spreadable as well as removable, emollient, non-staining, water soluble, longer shelf-life, bio-friendly, transparent with a pleasant appearance.
Patent Application Number: 3386/MUM/2014
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Adeno Associated Virus (AAV)
AAV is a small virus that infects humans and other primate species. It is not currently known to cause any disease, however, it causes a very mild immune response, lending further support to its apparent lack of pathogenicity. Its genomic structure consists of a replication (rep, left) and capsid (cap, right) gene flanked by two inverted terminal repeats (ITR’s). The rep gene is important for integration of wild AAV onto a specific site on human chromosome 19. So, our goal is to create a recombinant AAV in which the cap gene (and situationally the rep gene) are deleted and replaced by the gene of interest (transgene).
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Adeno Associated Virus (AAV)
AAV is a small virus that infects humans and other primate species. It is not currently known to cause any disease, however, it causes a very mild immune response, lending further support to its apparent lack of pathogenicity. Its genomic structure consists of a replication (rep, left) and capsid (cap, right) gene flanked by two inverted terminal repeats (ITR’s). The rep gene is important for integration of wild AAV onto a specific site on human chromosome 19. So, our goal is to create a recombinant AAV in which the cap gene (and situationally the rep gene) are deleted and replaced by the gene of interest (transgene).
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Adeno Associated Virus (AAV)
AAV is a small virus that infects humans and other primate species. It is not currently known to cause any disease, however, it causes a very mild immune response, lending further support to its apparent lack of pathogenicity. Its genomic structure consists of a replication (rep, left) and capsid (cap, right) gene flanked by two inverted terminal repeats (ITR’s). The rep gene is important for integration of wild AAV onto a specific site on human chromosome 19. So, our goal is to create a recombinant AAV in which the cap gene (and situationally the rep gene) are deleted and replaced by the gene of interest (transgene).
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Alternative Oxidase Activity Stimulating Chemical Composition And A Method For Reducing Hypoxia In Plants
The Present invention provide technique for improvements as solution to hypoxia generated in conventional plant tissue culture practices. It Provides a chemical compositions when used in effective concentration will improve plants yield, hypoxic tolerance of plants micro propagated through plant tissue culture practice. And, Chemical composition comprises high concentration of potassium nitrate, choline chloride, glutamine acid, L- Glycine, L-Cysteine, Adenine sulphate, D Ca- Pantothenate acid, Sodium silicate and succinic acid derivatives along with plant tissue culture medium and plant growth hormones. Said chemical compositions may be added during multiplication stage, shooting stage and rooting stage along with plant tissue culture medium.
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Electronic Urinal: Design And Method
The current invention has a unique feature that allows effective use of urinal waste to produce electric energy by Mass Flow Controller (MCF). In earlier days, some researchers attempted to integrate MFCs with Urinal systems. However, there is a gap in field trial studies describing pilot-scale MFC systems deployed under real conditions. The present invention has overcome those challenges to make the MFC based Urinal System scalable at large scale.
Patent Application Number: 201911005010
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Aerogel And Hybrid Aerogel-Hydrogel Hydrocolloid Materials To Trap And Release Functional Materials
The materials can be fabricated to hold particles with sizes ranging from 5 to 30nm. This can have applications in health, hygiene, fragrance, perfumery, food, agricultural sector.
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Escape Therapeutics’ Stem Cell Based Regenerative Medicine And Dermatology Technologies And Products
Escape Therapeutics has successfully worked on a number of novel and potentially disruptive technologies including peptides/ proteins and some of them are already in the market, either by themselves, or in collaboration, and has also out-licensed portfolios in the past. Their various technologies/ products can be applied for treating conditions such as Type I diabetes, Myocardial infarction and Chronic heart failure, Osteoarthritis, Scleroderma, thermal burn and radiation injury, Hyperpigmentation, Melanoma, Aging, Wound and scar etc. Escape Therapeutics is currently looking for licensing/sale of their Patent Portfolio (including stake in the entity as well) and/or for allied collaborations.
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Carbon Nanotube Based Paint Coating Technology
This breakthrough technology produces functionalized and dispersed multi-walled carbon nanotubes with better mechanical properties resulting in reduced paint coating costs and ownership costs.
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Carbon Nanotube Based Rubber Additive
This technology converts bundled carbon nanotubes into discrete, multi-walled CNTs functionalized for use as rubber additive.
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Immunotherapeutic Platform Technology Of Eutilex Co.
Eutilex has successfully developed Immunotherapeutics platforms which are proven effective as compared to existing solutions. Their various platform technologies can be applied for treating diverse incurable diseases including solid cancer. Eutilex is currently looking for license/ sale of their technology(ies) and/or for allied collaborations.
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Antifungal Oral Care Composition
This patented oral care composition is useful for treatment of oral candidiasis or oral thrush, denture stomatitis, gingivitis, angular chelitis caused Candida albicans. This is a herbal composition, that is, an ayurvedic medicine and is found to have no or negligible side effects. The composition has Sodium biborate as active agent along with other additives and excipients.
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